The LA Galaxy player has been approached by the Jewish organisation to appear either live or pre-recorded for the broadcast - which is famous for its dancing rabbis - on September 9.
The six-hour show is transmitted from Hollywood and broadcast across the United States.
"As soon as we heard that David Beckham was coming to Los Angeles, we knew we had to get him involved," said a Chabad insider. "Over the past 27 years, the Telethon has raised many millions of dollars that have supported community projects and people of all backgrounds. We hope our ideals will appeal to him to get involved."
Celebrities who have shown support to the annual telethon have included Bob Dylan, Whoopi Goldberg, Adam Sandler, Anthony Hopkins and cast members from TV sitcom Friends.